Olmesartan Medoxomil Olmetec Monotherapy Or In Combination With Hydrochlorothiazide Olmetec Plus For Hypertension

Olmesartan Medoxomil Olmetec Monotherapy Or In Combination With Hydrochlorothiazide Olmetec Plus For Hypertension. The therapeutic control of hypertension is still a global challenge and frequently requires combination therapy. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions.

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When administered concurrently the following drugs may interact with thiazide diuretics: • in patients with hypersensitivity to any component of olmesartan medoxomil and hydrochlorothiazide tablets see adverse reactions ( 6.1, 6.2) • in patients with anuria see warnings and precautions ( 5.3) and adverse reactions ( 6.1) • for coadministration with aliskiren in patients with diabetes see drug interactions ( 7.4). Single oral doses of amlodipine maleate equivalent to 40 mg amlodipine/kg and 100 mg amlodipine/kg in mice and rats, respectively, caused deaths.

Increases in serum lithium concentrations and lithium toxicity have been reported during concomitant administration of lithium with angiotensin ii receptor antagonists or hydrochlorothiazide.

It is not known whether olmesartan is excreted in human milk, but olmesartan is secreted at low concentration in the milk of lactating rats. The dialyzability of olmesartan is unknown. When pregnancy is detected, discontinue olmesartan medoxomil and hydrochlorothiaz. The mechanism of this effect has not been elucidated.