Long Term Prescribing Of New Oral Anticoagulants. Are there any new oral anticoagulants for atrial fibrillation? Key considerations include patient adherence, kidney and liver function, and potential interactions with concomitant drugs.
Making Connections Webinar: Warfarin versus the Novel Oral ... from i.ytimg.com Unfortunately, known severe renal impairment was only present in up to 7% of the subgroup of dabigatran 75 mg bd and results must be interpreted carefully. Around 16% of patients received dabigatran 75 mg bd and among these, none of the study outcomes were statistically significantly different from warfarin except for a lower risk of intracranial haemorrhage with dabigatran. See full list on academic.oup.com
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At the moment of publication of this review, rivaroxaban, dabigatran, and apixaban are approved for antithrombotic prevention in af by the european medicines agency (ema) and food and drug administration (fda).24 edoxaban has been recently approved by the fda but not yet by the ema. The fda, but no the ema, approved 75 mg bid for patients with creatinine clearance (crcl) of 1530 ml/min based on pharmacokinetic models, but that dose has not been studied in the pivotal study of dabigatran. Search info from 1,200+ medications with our easy to use search tool. Careful attention to patients' characteristics will ensure a correct prescription of antithrombotic therapies for patients with af (figure 1 ).
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